Coupling of tyrosine deprotonation and axial ligand exchange in nitrocytochrome c.
نویسندگان
چکیده
Here we report a spectroscopic, electrochemical and computational study of cytochrome c showing that nitration of Tyr74 induces Tyr deprotonation, which is coupled to Met/Lys axial ligand exchange, and results in concomitant gain of peroxidatic activity at physiological pH.
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ورودعنوان ژورنال:
- Chemical communications
دوره 50 20 شماره
صفحات -
تاریخ انتشار 2014